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. Author manuscript; available in PMC: 2016 Apr 12.
Published in final edited form as: Biomacromolecules. 2015 Dec 17;17(1):301–313. doi: 10.1021/acs.biomac.5b01419

Figure 4.

Figure 4

In vivo tumor as well as tumor vasculature targeting of labeled micellar system. Male athymic nude mice were orthotopically implanted with MIA PaCa-2 tumor. FC-labeled GE11-linked mixed micelles, unmodified micelles, and HW12-linked mixed micelles were intravenously administered at day 21. After 24 h, the mice were sacrificed; tumors were removed, for sectioning and immunostaining with anti-VE-cadherin (marker of endothelial cells). GE11-linked mixed micelles significantly accumulated in tumor neovasculature, whereas unmodified micelles and HW12-linked mixed micelles poorly accumulated in the tumor neovasculature. Scale bar, 100 μm.