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Pulmonary barriers to lung siRNA delivery (Merkel O.M. et al., 2014).
| Airway Defenses | Alveoli Defenses |
|---|---|
| Upper airway (nose, throat, and trachea) | Degradative Enzymes e.g. proteases, RNase |
| Bifurcations | Neutrophils |
| Mucus | Opsonins |
| Mucociliary Clearance | Surfactant |
| Cough Clearance | Complement |
| Airway epithelium | Alveolar Macrophages |
