Blood was treated with citrate buffer, plasma was then separated, treated again with citrate buffer, diluted with H2O and stored at −80°C for thiol analyses. Disulfides were measured on plasma-NEM obtained by RBC purification and stored at −80°C. At the indicated times protein thiols were measured by colorimetric conjugation with DTNB, LMM-SH (panel A), LMM-SS (panel B) and RSSP (panel C) were measured by HPLC analysis with fluorometric detection. n= 5.