Skip to main content
. Author manuscript; available in PMC: 2017 Apr 11.
Published in final edited form as: Cancer Cell. 2016 Mar 31;29(4):508–522. doi: 10.1016/j.ccell.2016.03.002

Figure 8. BBB function dictates medulloblastoma exposure and response to vincristine in vivo.

Figure 8

A. Growth inhibition assays of mouse medulloblastoma cells following 72 hour exposure to the indicated drugs. B. Kaplan-Meyer survival curves of mShhcontrol and mWntcontrol-medulloblastomas to vincristine therapy. C. Vincristine area under the curve (AUC) plots for plasma (left), tumour tissue fluid (middle) and KPT (right) in mice harbouring the indicated medulloblastomas. D. Kaplan-Meyer survival curves of mWntcontrol- or mWntWnt7a- medulloblastomas treated with vincristine therapy. *=P<0.05, **=P<0.005, Mann-Whitney.