Effect of phospholipid polar headgroup and substrate aggregation state on
LmPLC activity. (A) Relative activity of
LmPLC towards different phospholipids (6 mM) dispersed in
20 mM Triton X-100, 20 mM HEPES, 150 mM NaCl pH 6, 37°C, compared to the
% hydrolysis rate for PC (defined as 100). (B) Enzyme specific activity
is shown as a function of diC7PC concentration in 20 mM MES, 150 mM
NaCl, 50 μM Zn2+, 0.1 mg/mL BSA, pH 6. The black
solid line is the fit for monomeric diC7PC as substrate; the dashed
line is the fit for diC7PC micelles as substrates assuming a constant
monomer activity and a sharp phase separation of monomers and micelles. Data are
shown as mean ± SD, n = 3 independent experiments.