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. Author manuscript; available in PMC: 2017 Apr 12.
Published in final edited form as: Biochemistry. 2016 Apr 1;55(14):2122–2134. doi: 10.1021/acs.biochem.6b00145

Figure 2.

Figure 2

All RS enzymes use the site differentiated [4Fe-4S] cluster to catalyze the reductive cleavage of SAM. Upon reduction from the +2 to the +1 oxidation state the [4Fe-4S] mediates an inner sphere electron transfer to SAM generating the dAdo•. This strong oxidant then abstracts a H-atom from substrate to initiate a radical-mediated transformation.