Table II.
Baseline laboratory parameters for ambulatory children with HbSS in Lilongwe.
| Complete Blood Count | All (n=113) | Males (n=58) | Females (n=46) | Unit | p value |
|---|---|---|---|---|---|
| White blood cell count, median (IQR) | 16 (12.2-19.2) | 16.5 (12.8-19.6) | 15.9 (11.9-18.9) | ×109/l | 0.18 |
| Hb, mean (IQR) | 73 (69-79) | 72 (66-78) | 75 (70-79) | g/l | 0.12 |
| Haematocrit, mean (IQR) | 22.6 (21-24.6) | 22.2 (20-24.6) | 22.9 (21.3-24.7) | % | 0.14 |
| Mean Corpuscular Volume, mean (IQR) | 88.2 (83-94) | 88 (83-94) | 88.3 (82.5-94) | fl | 0.88 |
| Platelet Count | 450 (351-586) | 435.5 (364.5-565) | 485 (323-588) | ×109/l | 0.97 |
| Absolute Neutrophil Count | 5.39 (4.3-6.7) | 5.4 (4.5-6.5) | 5.4 (4.0-6.7) | ×109/l | 0.98 |
| Lymphocyte Count | 7.9 (5.9-10.8) | 8.6 (6.1-11.2) | 6.3 (5.7-10.2) | ×109/l | 0.03 |
| Serum Chemistries | All (n=115) | Males (n=62) | Females (n=53) | ||
|---|---|---|---|---|---|
| Creatinine, median (IQR) | 26.5 (17.6-26.5) | 26.5 (17.6-26.5) | 26.5 (17.6-35.6) | μmol/l | 0.15 |
| Total Bilirubin, median (IQR) | 29.1 (18.8-44.5) | 29.1 (18.8-42.8) | 29.1 (17.1-49.6) | μmol/l | 0.97 |
| Direct Bilirubin, median (IQR) | 10.3 (6.8-13.7) | 10.3 (6.8-13.7) | 10.3 (6.8-15.4) | μmol/l | 0.98 |
| Lactate Dehydrogenase, median (IQR) | 658 (527-773) | 664 (544-773) | 634 (517-772) | iu/l | 0.54 |
| Urine Dipstick | All (n=100) | Males (n=51) | Females (n=49) | ||
|---|---|---|---|---|---|
| Glucose, n (%) | 3 (3) | 0 | 3 (6.1) | 0.06 | |
| Bilirubin, n (%) | 12 (12) | 7 (13.7) | 5 (10.2) | 0.69 | |
| Specific gravity, median (IQR) | 1.015 (1.01-1.02) | 1.015 (1.01-1.015) | 0.82 | ||
| Blood, n (%) | 26 (26) | 10 (19.5) | 16 (32.7) | 0.09 | |
| pH, median (IQR) | 6 (5.5-6.3) | 5.5 (5.5-6) | 0.86 | ||
| Protein, n( %) | 7 (7) | 3 (5.9) | 4 (8.2) | 0.57 | |
| Urobilinogen, median (IQR) | 3.4 (3.4-17.1) | 3.4 (3.4-17.1) | μmol/l | 0.64 | |
| Positive nirtrite, n(%) | 7 (7) | 5 (9.8) | 2 (4.1) | 0.31 | |
| Leucocytes, n( %) | 19 (19) | 0 | 19 (38.8) | <0.001 |