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Comprehensive assays of liver-specific functions of hepatocyte/fibroblast co-culture and hepatocyte culture. a) Albumin secretion and b) urea synthesis of HepG2/NIH-3T3 co-culture and HepG2 culture measured over seven days. The liver-specific functions enhanced by the co-culture of hepatocytes and fibroblasts in the 3D core-shell spheroids are statistically significant (*p<0.01).
