Table 4. Mean ± SD values of enrofloxacin (ER) and ciprofloxacin (CP) in feces following intravenous and subcutaneous administrations at doses of 5.0 and 7.5 mg/kg BW in Thai swamp buffaloes (n=5 per group).
Time (hr) | 5.0 mg/kg | 7.5 mg/kg | ||||||
---|---|---|---|---|---|---|---|---|
Intravenous | Subcutaneous | Intravenous | Subcutaneous | |||||
ER (µg/ml) | CP (µg/ml) | ER (µg/ml) | CP (µg/ml) | ER (µg/ml) | CP (µg/ml) | ER (µg/ml) | CP (µg/ml) | |
0–4 | NF | NF | 0.03 ± 0.003* | 0.05 ± 0.04* | 0.24 ± 0.05 | ND | NF | NF |
4–12 | 3.63 ± 1.12 | 3.46 ± 0.72 | 0.57 ± 0.33* | 0.20 ± 0.17* | 2.06 ± 0.13 | 0.51 ± 0.45 | 0.33 ± 0.06* | 0.14 ± 0.06 |
12–24 | 0.10 ± 0.33 | 0.32 ± 0.03 | 0.62 ± 0.14* | 0.28 ± 0.08 | 0.24 ± 0.10 | 0.20 ± 0.08 | 0.86 ± 0.53* | 0.53 ± 0.21* |
NF: no fecal collection; ND: not detected. *P<0.05 (statistically significant value if compared to the corresponding i.v. group).