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The genomic structure of wild-type HSV-1 (F) and recombinant strains. Line 1, wild-type HSV-1 (F) genome; line 2, the recombinant strain YK322, in which both copies of ICP0 are fused to a fragment consisting of a Myc epitope, a tobacco etch virus protease cleavage site and a Flag epitope (MEF); line 3, the recombinant strain R7910, from which both copies of ICP0 gene have been deleted.
