Table 3.
Summary of the clinicopathological significance of miR-196 family molecules in digestive tract cancers.
| Cancers. | Family member | Diagnostic potential | Clinicopathological or prognostic association | References |
|---|---|---|---|---|
| Oral cancer #* | miR-196a, miR-196b | Differentiate normal, pre-cancer and cancer | Associated with lymph node metastasis | [25][68] |
| Head-neck cancer # | miR-196a | Differentiate normal and cancer | Associated with radioresistance | [59, 24] |
| Esophageal cancer # | miR-196a | Differentiate normal, pre-cancer and cancer | -- | [60] |
| Gastric cancer #* | miR-196a,miR-196b | -- | Associated with recurrence and shorter survival | [27,28,34,45,61] |
| Colorectal cancer # | miR-196a, miR-196b | -- | Associated with shorter survival | [35] |
| Pancreatic cancer* | miR-196a | Differentiate normal and cancer | Associated with recurrence and shorter survival | [66, 67] |
#Determination of miR-196 in tissue specimens, * Determination of miR-196 in blood specimens.