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. 2016 Apr 13;7:515. doi: 10.3389/fmicb.2016.00515

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Copyright © 2016 Krause and Amer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Legionella pneumophila-induced Inflammasome Pathways in restrictive macrophages. Detection of cytosolic flagellin by Naip5/Nlrc4 (canonical inflammasome) leads to cleavage of caspase-1, cytokine release, pyroptosis and bacterial growth restriction. Flagellin-independent recognition of L. pneumophila involves the activation of caspase-1 downstream of caspase-11 (non-canonical inflammasome) as well as caspase-1-independent defense strategies executed by caspase-11. Both caspase-1 and caspase-11 promote phagosome-lysosome fusion via modulation of the actin cytoskeleton.