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Working model for the role of the CD2AP adaptor scaffold in the coordination of NGF signaling. A, Upon NGF stimulation, CD2AP coordinates the recruitment of TrkA and p85, leading to activation of AKT and the concomitant coordination of actin dynamics through cortactin-Arp2/3, resulting in filopodia formation and receptor endocytosis. B, Proposed structure of a Rab5-decorated CD2AP+ endosome. CD2AP may act as a scaffold for AKT association with endosomes.
