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. 2016 Apr 13;36(15):4362–4376. doi: 10.1523/JNEUROSCI.3781-15.2016

Figure 1.

Figure 1.

SAI DRG neurons survive following Merkel cell deletion but lose the expression of TrkB, TrkC, and Ret. A, B, Immunostaining for K8 and NF200 in the skin of P21 control littermate and K14; Atoh1CKO mice demonstrates touch dome innervation. C, D, Immunostaining for NF200 in T7 DRG sections from P21 control littermate and K14; Atoh1CKO mice. E–J, N–Q, Immunostaining for TrkB and TrkC (E–J) or TrkC and Ret (N–Q) in T7 DRG sections from E13.5, P0 and P21 control littermate, and K14; Atoh1CKO mice. K–M, R, S, Percentages of Islet1/2+ T7 DRG neurons that were TrkB+ (K), TrkC+ (L), TrkC+TrkB+ (M), NF200+Ret+ (R), and TrkC+Ret+ (S) in E13.5, E16.5, P0 and P21 control, and K14; Atoh1CKO mice (n ≥ 3 mice/genotype/age). In photographs, asterisks indicate double-labeled cells. In graphs, error bars represent the SEM, and asterisks indicate statistically significant differences between control and K14; Atoh1CKO mice. *p < 0.05; **p < 0.01; ***p < 0.001. Scale bar, 100 μm.