Table 1.
Protein | Age | Control | K14; Atoh1CKO | n | p Value |
---|---|---|---|---|---|
Islet 1/2 | E13.5 | 5025 ± 168 | 5170 ± 97 | 23 | 0.45 |
E16.5 | 4974 ± 165 | 5344 ± 201 | 36, 32 | 0.16 | |
P0 | 4639 ± 124 | 4618 ± 128 | 43 | 0.91 | |
P21 | 5060 ± 183 | 5028 ± 171 | 26, 24 | 0.90 | |
NF200 | E13.5 | 742 ± 90 | 823 ± 41 | 4 | 0.44 |
E16.5 | 762 ± 16 | 793 ± 42 | 4 | 0.51 | |
P0 | 719 ± 22 | 747 ± 42 | 12 | 0.56 | |
P21 | 1105 ± 89 | 1002 ± 19 | 3 | 0.32 | |
TrkB | E13.5 | 4.5 ± 0.48% | 4.1 ± 0.26% | 3 | 0.49 |
E16.5 | 8.5 ± 0.59% | 6.3 ± 0.41% | 7, 6 | 0.02 | |
P0 | 8.6 ± 0.63% | 7.0 ± 0.42% | 13 | 0.05 | |
P21 | 10.7 ± 1.33% | 10.4 ± 0.20% | 3 | 0.83 | |
TrkC | E13.5 | 4.7 ± 0.27% | 4.7 ± 0.27% | 12 | 0.95 |
E16.5 | 6.1 ± 0.43% | 5.2 ± 0.40% | 21, 18 | 0.12 | |
P0 | 8.6 ± 0.34% | 6.7 ± 0.42% | 16 | 0.002 | |
P21 | 11.0 ± 0.98% | 7.2 ± 0.50% | 12 | 0.003 | |
TrkB/TrkC | E13.5 | 0.1 ± 0.01% | 0.1 ± 0.01% | 3 | 0.46 |
E16.5 | 1.2 ± 0.24% | 1.1 ± 0.23% | 7, 6 | 0.59 | |
P0 | 4.2 ± 0.52% | 1.6 ± 0.62% | 6 | 0.01 | |
P21 | 3.7 ± 0.51% | 4.1 ± 0.14% | 3 | 0.51 | |
NF200/Ret | E13.5 | 2.9 ± 0.52% | 2.7 ± 0.30% | 4 | 0.71 |
E16.5 | 3.5 ± 0.48% | 3.1 ± 0.15% | 4 | 0.45 | |
P0 | 2.0 ± 0.07% | 2.3 ± 0.19% | 6 | 0.17 | |
P21 | 9.8 ± 0.33% | 6.6 ± 0.41% | 3 | 0.004 | |
TrkC/Ret | E13.5 | 0.6 ± 0.05% | 0.6 ± 0.03% | 3 | 0.68 |
E16.5 | 2.4 ± 0.57% | 2.4 ± 0.72% | 4 | 0.97 | |
P0 | 2.0 ± 0.18% | 2.2 ± 0.34% | 4 | 0.70 | |
P21 | 5.9 ± 0.52% | 2.9 ± 0.32% | 6 | 0.0006 | |
PV | E13.5 | 1.3 ± 0.15% | 1.4 ± 0.12% | 6 | 0.81 |
E16.5 | 2.9 ± 0.37% | 2.5 ± 0.29% | 10, 8 | 0.41 | |
P0 | 2.8 ± 0.25% | 2.2 ± 0.18% | 6 | 0.10 | |
P21 | 2.5 ± 0.21% | 2.3 ± 0.42% | 6 | 0.63 | |
PV/TrkC | E13.5 | 1.3 ± 0.15% | 1.4 ± 0.12% | 6 | 0.81 |
E16.5 | 2.9 ± 0.37% | 2.50 ± 0.29% | 10, 8 | 0.41 | |
P0 | 2.8 ± 0.25% | 2.2 ± 0.18% | 6 | 0.10 | |
P21 | 2.5 ± 0.21% | 2.3 ± 0.42% | 6 | 0.63 | |
NF200/γENaC | P21 | 11.1 ± 0.17% | 7.0 ± 0.37% | 3 | 0.0006 |
NF200/ASIC1 | P21 | 12.9 ± 1.61% | 12.7 ± 0.73% | 3 | 0.88 |
NF200/DOR | P21 | 13.1 ± 0.80% | 11.7 ± 0.48% | 3 | 0.20 |
Values are given as T7 DRG neuron counts and the percentages of total neuron numbers expressing different markers in K14; Atoh1CKO and control littermate mice, and are reported as the mean ± SEM, unless otherwised indicated.