Table 2.
Marker expression for T7 DRG neurons in the absence of BDNF
| Protein | Mice |
n | p Value | ||
|---|---|---|---|---|---|
| Control | K14; BdnfCKO | Atoh1CreER-T2; BdnfCKO | |||
| P0 | |||||
| Islet 1/2 | 5278 ± 144 | 5623 ± 122 | 28, 29 | 0.07 | |
| TrkB | 10.6 ± 0.43% | 9.2 ± 0.39% | 12 | 0.02 | |
| TrkC | 11.1 ± 0.47% | 8.8 ± 0.48% | 12 | 0.003 | |
| TrkB/TrkC | 3.6 ± 0.49% | 2.0 ± 0.36% | 6, 5 | 0.04 | |
| NF200/Ret | 2.2 ± 0.14% | 2.6 ± 0.28% | 6 | 0.21 | |
| PV | 4.3 ± 0.23 | 3.9 ± 0.29 | 6 | 0.31 | |
| E14.5 Tam → E18.5 | |||||
| Islet 1/2 | 6050 ± 199 | 5968 ± 215 | 7 | 0.78 | |
| TrkB | 10.6 ± 0.11% | 9.3 ± 0.27% | 4 | 0.004 | |
| TrkC | 11.1 ± 0.34% | 8.7 ± 0.39% | 6 | 0.001 | |
| TrkB/TrkC | 7.1 ± 0.47% | 4.9 ± 0.36% | 6 | 0.005 | |
| P0–P2 Tam → P23 | |||||
| Islet 1/2 | 4776 ± 213 | 4928 ± 350 | 3 | 0.73 | |
| TrkC | 12.0 ± 1.85% | 12.6 ± 2.22% | 3 | 0.84 | |
| TrkC/Ret | 4.9 ± 0.27% | 5.4 ± 0.79% | 3 | 0.59 | |
Values are given as T7 DRG neuron counts and the percentages of total neuron numbers expressing different markers in P0 K14; BdnfCKO and E18.5 Atoh1CreER-T2; BdnfCKO mice given tamoxifen at E14.5; P23 Atoh1CreER-T2; BdnfCKO mice given tamoxifen from P0 to P2; and control littermate mice; and are reported as the mean ± SEM, unless otherwised indicated.