Table 4. Adjusted associations between cinacalcet use and clinical outcomes in patients with baseline iPTH ≥300 pg/ml, computed using marginal structural modelsa.
Adjusted RR | 95% CI | p-value | |
---|---|---|---|
Death due to any causeb | 0.75 | 0.55–1.03 | 0.073 |
Death due to cardiovascular diseaseb | 0.90 | 0.56–1.47 | 0.683 |
Cardiovascular hospitalization or deathc | 0.71 | 0.53–0.94 | 0.016 |
RR: incidence rate ratio, 95% CI: 95% confidence interval.
aEstimated from weighted Poisson regression models. To calculate weight, probability of initiating cinacalcet was predicted by age, sex, vintage, primary renal disease, cardiovascular disease, lung disease, liver disease, malignancy, parathyroidectomy, time-varying value of VDRA, phosphate binder, serum Ca, serum inorganic Phosphorus, serum iPTH, dialysate Ca, Kt/V, serum Alb, BMI, Hgb, interaction terms of treatment variables and MBD variables, and visit number.
bEstimated from case-cohort studies.
cEstimated from cohort study.