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. 2016 Apr 13;6:24334. doi: 10.1038/srep24334

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Copyright © 2016, Macmillan Publishers Limited

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(a) Voltage and (b) alternans phase maps of in silico NRVM cultures corresponding to the experimental group with the lowest CV, containing different percentages of randomly distributed MFBs. Alternans was not observed in monolayers with 100% cardiomyocytes (a1,b1); in the presence of 10% MFBs, some portions of the monolayer began to show unstable alternans (a2,b2). In this scenario wavebreaks could occur, but these failed to develop into reentrant circuits. With 15% MFBs (a3,b3) a limited number of large APIs began to form and; unstable reentry could be initiated. With 25% MFBs (a4,b4), multiple APIs started to form, which evolved dynamically giving rise to stable reentrant circuits. Raising the percentage of MFBs to 30% further increased the pro-arrhythmicity of the substrate (a5,b5).