TABLE 5.
Combined Study Data Model Fits and Slope Estimates in Relationship to Occupational and Personal-Diagnostic-Medical (PDM) Doses, by Limiting to Members of Cohort with Specified Level of Dose, using Regression-Calibration Adjusted Occupational Doses, with 95% Profile Likelihood Confidence Intervals, Adjusted for Overdispersiona
| Dose range used (mGy) (occupational + personal-diagnostic dose) | Occupational linear dose parameter only (translocations/100 CEb/Gy) | P valuec | PDM linear dose parameter only (translocations/100 CEb/Gy) only | P valuec | Occupational + PDM linear dose parameter (constrained equal) (translocations/100 CEb/Gy) | P valuec |
|---|---|---|---|---|---|---|
| Full | 7.0 (1.2, 12.9) | 0.0188 | 4.4 (2.2, 6.7) | <0.0001 | 4.4 (2.5, 6.5) | <0.0001 |
| <250 | 5.9 (–0.3, 12.1) | 0.0607 | 5.0 (2.3, 7.8) | 0.0002 | 5.2 (2.7, 7.7) | <0.0001 |
| <200 | 5.9 (–0.3, 12.1) | 0.0620 | 4.8 (1.9, 7.8) | 0.0011 | 5.1 (2.4, 7.7) | 0.0001 |
| <150 | 6.3 (0.3, 12.4) | 0.0411 | 4.2 (0.6, 7.9) | 0.0210 | 4.8 (1.7, 7.9) | 0.0023 |
| <100 | 9.0 (1.3, 16.7) | 0.0225 | 7.2 (1.5, 13.0) | 0.0137 | 8.4 (3.9, 12.9) | 0.0004 |
| <50 | –4.9 (–16.5, 7.1) | 0.4222 | 13.4 (3.7, 23.4) | 0.0076 | 8.3 (–0.5, 16.9) | 0.0672 |
a
Background model is adjusted for age, study group (CTS-I vs. II), sex × study group; a 6-year period of latency is assumed.
b
Per whole chromosome equivalents (CE), i.e., the normalized translocation frequency per 100 cells assumed to have full-genome painting done of their nuclear DNA.
c
P value refers to the improvement in fit compared with fit of a model without radiation dose terms.