Table 3.
Results from general linear regression models evaluating the association between PBDEs (ng/g serum) and thyroid function tests (51 participants, 137 serum samples).
| TFT/Model | BDE-28 β (95% CI) | p-Value | BDE-47 β (95% CI) | p-Value | BDE-99 β (95% CI) | p-Value | BDE-100 β (95% CI) | p-Value | BDE-153 β (95% CI) | p-Value |
|---|---|---|---|---|---|---|---|---|---|---|
| TT4 (μg/dL) | ||||||||||
| Model A | –51 (–110, 6.2) | 0.08 | –2.7 (–4.8, –0.61) | 0.01 | –7.3 (–15, 0.042) | 0.05 | –8.4 (–14, –2.5) | 0.01 | –2.8 (–5.5, 0.04) | 0.05 |
| Model B | –33 (–95, 29) | 0.29 | –2.3 (–4.5, –0.18) | 0.03 | –6.4 (–14, 0.93) | 0.09 | –7.5 (–14, –1.4) | 0.02 | –2.4 (–5.2, 0.43) | 0.10 |
| Model C | –34 (–97, 28) | 0.28 | –2.6 (–4.7, –0.35) | 0.02 | –7.6 (–15, –0.06) | 0.05 | –7.8 (–14, –1.6) | 0.01 | –2.3 (–5.2, 0.61) | 0.12 |
| TSH ln(μIU/mL)a | ||||||||||
| Model A | 0.29 (–28, 28) | 0.99 | 0.32 (–0.71, 1.4) | 0.54 | 1.6 (–2.1, 5.3) | 0.39 | 1.3 (–1.6, 4.2) | 0.37 | 0.97 (–0.34, 2.3) | 0.15 |
| Model B | –11 (–41, 18) | 0.45 | 0.10 (–0.95, 1.2) | 0.85 | 1.2 (–2.6, 4.9) | 0.54 | 0.84 (–2.1, 3.8) | 0.58 | 0.83 (–0.49, 2.2) | 0.21 |
| Model C | –11 (–42, 20) | 0.49 | 0.17 (–0.92, 1.3) | 0.75 | 1.5 (–2.5, 5.4) | 0.46 | 0.92 (–2.2, 4.0) | 0.55 | 0.81 (–0.58, 2.2) | 0.25 |
| fT4 ln(ng/dL)a | ||||||||||
| Model A | –0.40 (–7.5, 6.7) | 0.92 | –0.13 (–0.39, 0.1) | 0.35 | –0.72 (–1.7, 0.23) | 0.14 | 0.27 (–0.47, 1.0) | 0.47 | 0.40 (–0.09, 0.72) | 0.01 |
| Model B | 1.1 (–6.6, 8.9) | 0.77 | –0.10 (–0.4, 0.17) | 0.46 | –0.67 (–1.6, 0.30) | 0.17 | 0.35 (–0.41, 1.1) | 0.37 | 0.42 (0.10, 0.75) | 0.01 |
| Model C | 0.42 (–7.3, 8.1) | 0.91 | –0.13 (–0.40, 0.1) | 0.34 | –0.83 (–1.8, 0.14) | 0.09 | 0.21 (–0.54, 0.95) | 0.58 | 0.35 (0.03, 0.67) | 0.04 |
| TT3 ln(ng/mL)a | ||||||||||
| Model A | 0.01 (–0.3, 0.3) | 0.99 | –0.01 (–0.3, 0.3) | 0.94 | 0.12 (–0.91, 1.1) | 0.82 | –0.28 (–1.0, 0.47) | 0.46 | –0.28 (–0.6, 0.05) | 0.10 |
| Model B | 2.2 (–5.9, 10) | 0.60 | 0.03 (–0.25, 0.3) | 0.82 | 0.23 (–0.81, 1.3) | 0.67 | –0.20 (–0.98, 0.6) | 0.61 | –0.27 (–0.6, 0.08) | 0.13 |
| Model C | 2.2 (–5.9, 10) | 0.62 | 0.04 (–0.24, 0.3) | 0.77 | 0.21 (–0.84, 1.3) | 0.69 | –0.13 (–0.9, 0.64) | 0.73 | –0.19 (–0.54, 0.2) | 0.28 |
|
Abbreviations: β, beta-estimate; BDE, bromodiphenyl ether; CI, confidence interval; fT4, free thyroxine; p, p-value; TFT, thyroid function test; TT3, total triiodothyronine; TT4, total thyroxine; TSH, thyroid-stimulating hormone; SG, specific gravity. Model A: Exposure only, no covariates. Model B: Adjusted for serum lipids only. Model C: Adjusted for serum lipids, age, sex, BMI, urine iodide, urine perchlorate, urine thiocyanate, and urine specific gravity. All covariates other than sex were modeled as untransformed continuous variables. aDependent variables are natural log–transformed. | ||||||||||