Table 1.
Available data for dioxin-like chemicals for 4,340 participants studied in the 1999–2004 National Health and Nutrition Examination Surveys (NHANES).
| Chemical (pg/g serum lipid) | TEFa | Number of observations (percent < LOD)b | ||
|---|---|---|---|---|
| Cycle 1: 1999–2000 | Cycle 2: 2001–2002 | Cycle 3: 2003–2004 | ||
| Chlorinated dibenzo-p-dioxins | ||||
| 2,3,7,8-TCDD | 1.00000 | 1,565 (100) | 1,092 (87) | 1,683 (63) |
| 1,2,3,7,8-PnCDD | 1.00000 | 1,554 (87) | 1,087 (64) | 1,683 (47) |
| 1,2,3,4,7,8-HxCDD | 0.10000 | 0 | 1,090 (65) | 1,665 (75) |
| 1,2,3,6,7,8-HxCDD | 0.10000 | 1,523 (61) | 1,086 (6) | 1,673 (19) |
| 1,2,3,7,8,9-HxCDD | 0.10000 | 1,514 (87) | 1,088 (58) | 1,672 (73) |
| 1,2,3,4,6,7,8-HpCDD | 0.01000 | 1,519 (42) | 1,070 (1) | 1,677 (3) |
| 1,2,3,4,6,7,8,9-OCDD | 0.00030 | 1,544 (40) | 1,033 (18) | 1,656 (16) |
| Chlorinated dibenzofurans | ||||
| 2,3,4,7,8-PnCDF | 0.30000 | 1,546 (62) | 1,081 (33) | 1,675 (35) |
| 2,3,7,8-TCDFc | 0.10000 | 1,546 (100) | 1,084 (99) | 1,673 (97) |
| 1,2,3,4,7,8-HxCDF | 0.10000 | 1,530 (64) | 1,078 (17) | 1,670 (40) |
| 1,2,3,6,7,8-HxCDF | 0.10000 | 1,538 (80) | 1,089 (28) | 1,671 (51) |
| 1,2,3,7,8,9-HxCDFc | 0.10000 | 1,519 (100) | 1,078 (100) | 1,668 (100) |
| 2,3,4,6,7,8-HxCDFc | 0.10000 | 1,527 (98) | 1,083 (89) | 1,669 (95) |
| 1,2,3,7,8-PnCDFc | 0.03000 | 1,559 (100) | 1,085 (99) | 1,671 (98) |
| 1,2,3,4,6,7,8-HpCDF | 0.01000 | 1,372 (57) | 1,071 (10) | 1,661 (10) |
| 1,2,3,4,7,8,9-HpCDFc | 0.01000 | 0 | 1,073 (100) | 1,656 (94) |
| 1,2,3,4,6,7,8,9-OCDF | 0.00030 | 1,516 (99) | 1,058 (100) | 1,654 (73) |
| Dioxin-like polychlorinated biphenyls | ||||
| 3,3’,4,4’,5-Pentachlorobiphenyl (PCB126) | 0.10000 | 1,544 (51) | 1,079 (11) | 1,664 (7) |
| 3,3’,4,4’,5,5’-Hexachlorobiphenyl (PCB169) | 0.03000 | 1,526 (53) | 1,076 (11) | 1,668 (42) |
| 3,4,4’,5-Tetrachlorobiphenyl (PCB81) | 0.00030 | 1,528 (99) | 1,070 (100) | 1,664 (64) |
| 2,3,3’,4,4’-Pentachlorobiphenyl (PCB105) | 0.00003 | 1,510 (89) | 1,092 (76) | 1,637 (3) |
| 2,3’,4,4’,5-Pentachlorobiphenyl (PCB118) | 0.00003 | 1,520 (60) | 1,092 (24) | 1,642 (0) |
| 2,3,3’,4,4’,5-Hexachlorobiphenyl (PCB156) | 0.00003 | 1,501 (71) | 1,087 (40) | 1,645 (18) |
| 2,3,3’,4,4’,5’-Hexachlorobiphenyl (PCB157) | 0.00003 | 1,497 (97) | 1,086 (90) | 1,631 (36) |
| 2,3’,4,4’,5,5’-Hexachlorobiphenyl (PCB167) | 0.00003 | 1,504 (95) | 1,085 (87) | 1,636 (42) |
| 2,3,3’,4,4’,5,5’-Heptachlorobiphenyl (PCB189) | 0.00003 | 0 | 1,090 (100) | 1,596 (76) |
|
A lone zero in the 1999–2000 column indicates that the chemical in that row was excluded from the mixtures analyses owing to missing data in at least one cycle (i.e., Cycle 1). Abbreviations: ANA, antinuclear antibodies; HpCDD, heptachlorodibenzo-p-dioxin; HpCDF, heptachlorodibenzofuran; HxCDD, hexachlorodibenzo-p-dioxin; HxCDF, hexachlorodibenzofuran; LOD, limit of detection; OCDD, octachlorodibenzo-p-dioxin; OCDF, octachlorodibenzofuran; PCB, polychlorinated biphenyl; PnCDD, pentachlorodibenzo-p-dioxin; PnCDF, pentachlorodibenzofuran; TCDD, tetrachlorodibenzo-p-dioxin; TCDF, tetrachlorodibenzofuran; TEF, toxic equivalency factor. aThe TEF values are the 2005 World Health Organization estimates (Van den Berg et al. 2006). bThe percent below the LOD can vary over time because it is a function of the concentration distribution, the volume of sample available for analysis, and the analytic method used to evaluate the sample. cFor survey years 1999–2004 combined, the overall percent below the LOD was ≥ 90%. | ||||