Table 3.
Height, waist circumference, and BMI by age in low, medium, and high combined NIS inhibitor biomarker exposure categoriesa: predicted means and differences (95% CIs) based on mixed effects modelsb in 940 girls, BCERP 2004–2007.
| Age (years)c | Low-exposure category | Medium-exposure category | High-exposure category | Difference between low and high (95% CI) | p-Valued |
|---|---|---|---|---|---|
| Height (cm) | |||||
| 7 | 121.2 (120.1, 122.2) | 120.6 (120.0, 121.3) | 120.1 (119.1, 121.2) | 1.0 (–0.4, 2.5) | 0.172 |
| 8 | 129.0 (127.9, 130.0) | 127.8 (127.2, 128.5) | 126.9 (125.9, 127.9) | 2.1 (0.6, 3.5) | 0.004 |
| 9 | 136.0 (135.0, 137.1) | 134.5 (133.9, 135.2) | 133.4 (132.3, 134.4) | 2.7 (1.3, 4.1) | < 0.001 |
| 10 | 142.4 (141.3, 143.4) | 140.8 (140.1, 141.4) | 139.5 (138.5, 140.6) | 2.8 (1.4, 4.3) | < 0.001 |
| 11 | 148.0 (146.9, 149.0) | 146.5 (145.9, 147.2) | 145.4 (144.4, 146.4) | 2.6 (1.1, 4) | < 0.001 |
| 12 | 152.8 (151.8, 153.9) | 151.8 (151.1, 152.5) | 151.0 (150.0, 152.0) | 1.8 (0.4, 3.3) | 0.011 |
| 13 | 157.0 (155.9, 158.0) | 156.6 (155.9, 157.3) | 156.3 (155.2, 157.3) | 0.7 (–0.8, 2.1) | 0.356 |
| Waist circumference (cm) | |||||
| 7 | 57.1 (55.5, 58.8) | 58.7 (57.7, 59.8) | 58.0 (56.4, 59.7) | –0.9 (–3.2, 1.4) | 0.444 |
| 8 | 61.3 (59.7, 62.9) | 62.2 (61.2, 63.2) | 61.1 (59.5, 62.7) | 0.2 (–2, 2.4) | 0.830 |
| 9 | 65.2 (63.6, 66.8) | 65.6 (64.6, 66.6) | 64.1 (62.5, 65.7) | 1.2 (–1, 3.3) | 0.295 |
| 10 | 68.8 (67.2, 70.4) | 68.8 (67.8, 69.8) | 67.0 (65.4, 68.5) | 1.9 (–0.3, 4.1) | 0.091 |
| 11 | 72.1 (70.5, 73.8) | 71.9 (70.9, 72.9) | 69.7 (68.2, 71.3) | 2.4 (0.2, 4.6) | 0.032 |
| 12 | 75.2 (73.5, 76.8) | 74.9 (73.9, 75.9) | 72.4 (70.9, 74.0) | 2.7 (0.5, 4.9) | 0.016 |
| 13 | 77.9 (76.2, 79.5) | 77.7 (76.7, 78.7) | 75.0 (73.4, 76.6) | 2.8 (0.6, 5) | 0.013 |
| BMI (kg/m2) | |||||
| 7 | 16.3 (15.6, 16.9) | 16.7 (16.3, 17.1) | 16.4 (15.7, 17.0) | –0.1 (–1, 0.8) | 0.871 |
| 8 | 17.3 (16.6, 17.9) | 17.5 (17.1, 17.9) | 17.0 (16.4, 17.6) | 0.2 (–0.6, 1.1) | 0.604 |
| 9 | 18.2 (17.6, 18.8) | 18.3 (17.9, 18.7) | 17.7 (17.1, 18.3) | 0.5 (–0.4, 1.3) | 0.259 |
| 10 | 19.1 (18.5, 19.7) | 19.1 (18.7, 19.5) | 18.4 (17.8, 19.0) | 0.7 (–0.1, 1.6) | 0.100 |
| 11 | 20.0 (19.4, 20.6) | 20.0 (19.6, 20.4) | 19.1 (18.5, 19.7) | 0.9 (0.1, 1.8) | 0.038 |
| 12 | 20.9 (20.2, 21.5) | 20.8 (20.4, 21.2) | 19.8 (19.2, 20.4) | 1.1 (0.2, 1.9) | 0.015 |
| 13 | 21.7 (21.1, 22.3) | 21.7 (21.3, 22.1) | 20.5 (19.9, 21.2) | 1.2 (0.3, 2) | 0.008 |
| aLow group is below the median concentration of all three NIS biomarkers; high group is above the median concentration of all three NIS biomarkers; medium group includes all the others. bPredicted means and differences were computed from the final model (adjusted for race/ethnicity and site) using the LSMEANS function in Proc Mixed SAS version 9.4. cNo estimate was provided for age 6 years due to small sample of girls who were exactly 6 years old at enrollment, truncated at age 13. dSignificance of the difference between the low- and high-exposure category. | |||||