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. 2015 Sep 15;124(4):445–451. doi: 10.1289/ehp.1409437

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IL6 promoter activity by haplotype alleles. Luciferase reporter construct containing haplotype allele A-G-A8T12-C (Risk HAP) that carried variant alleles for rs1800797 (A) and rs1800795 (C) had significantly higher reporter activity than was observed for G-G-A10T11-G (Reference HAP) in HEK293 (p-value = 3.42 × 10^–6), HFL1 (p-value = 1.86 × 10^–5), and HBEC2 (p-value = 6.2 × 10^–4). The height of the bar is the average luciferase activity standardized by the levels observed for G-G-A10T11-G set to one. The error bar is the standard deviation.