Table 4.

Association between rs1800797 and IL6 expression in primary human bronchial epithelial cells and lymphoblastic cell lines.

Tissuea	rs1800797	n	IL6 expression (mean ± SD)	p-Value
Human bronchial epithelial cells				0.009b
	GG	42	0.0016 ± 0.0019
	GA	32	0.0031 ± 0.0036
	AA	11	0.0041 ± 0.0038
Lymphoblastic cell lines				0.034c
	GG	18	6.18 ± 0.33
	GA	43	6.19 ± 0.33
	AA	18	6.36 ± 0.37
aPrimary human bronchial epithelial cell (BEC) cultures (n = 85) were established from cells obtained by bronchoscopy from current or former smokers examined at the pulmonary clinic of University of New Mexico Hospital. BEC cultures established from unaffected sites were used for this experiment for patients with subsequent lung cancer diagnosis. Epstein-Barr virus–transformed lymphoblastoid cell lines (n = 79) from CEU families (Utah residents with ancestry from northern/western Europe) were established by the HapMap project. bGeneralized linear model with adjustment for lung cancer diagnosis status. rs1800797 genotype was coded as 0, 1, or 2 for GG, GA, or AA genotype, respectively. IL6 expression was expressed as relative quantification with β-actin as the endogenous control. cLikelihood ratio test implemented in MERLIN was used to evaluate the association between rs1800797 and IL6 expression (GI_10834983-S). The family structure and sex were included in the models for covariate adjustment.