Table 1.
p16INK4A expression in correlation with clinical parameters and HPV status in Kazakh patients with ESCC
| Clinical properties | Total | p16 expression (n/%) | ||
|---|---|---|---|---|
| Negative (%) | Positive (%) | P value | ||
| Gender | ||||
| Male | 103 | 85(66.4 %) | 18(60.0 %) | 0.507 |
| Female | 55 | 43(33.6 %) | 12(40.0 %) | |
| Age (mean) | ||||
| < 58 | 85 | 60(48.0 %) | 13(50.0 %) | 0.853 |
| ≥ 58 | 67 | 65(52.0 %) | 13(50.0 %) | |
| Histopathological grade | ||||
| Well | 38 | 34(27.2 %) | 4(13.3 %) | 0.268 |
| Moderate | 97 | 76(60.8 %) | 21(70.0 %) | |
| Poor | 20 | 15(12.0 %) | 5(16.7 %) | |
| Invasion depth | ||||
| T1-T2 | 78 | 63(53.8 %) | 15(51.7 %) | 0.838 |
| T3-T4 | 68 | 54(46.2 %) | 14(48.3 %) | |
| Lymphatic invasion | ||||
| N0 | 66 | 48(42.5 %) | 18(64.3 %) | 0.038 |
| N1-N3 | 75 | 65(57.5 %) | 10(35.7 %) | |
| TNM Staging | ||||
| I/II | 76 | 59(60.8 %) | 17(77.3 %) | 0.147 |
| III/IV | 43 | 38(39.2 %) | 5(22.7 %) | |
| HPV infection | ||||
| Negative | 66 | 52(53.1 %) | 14(60.9 %) | 0.499 |
| Positive | 55 | 46(46.9 %) | 9(39.1 %) | |
P < 0.05 indicates a significant association among the variables