Table 2.

p53 expression in relation to clinical parameters and HPV status in Kazakh patients with ESCC

Clinical properties	Total	p53 expression (n/%)
		Negative (%)	Positive (%)	P value
Gender
Male	106	10(52.6 %)	96(66.7 %)	0.228
Female	57	9(47.4 %)	48(33.3 %)
Age (mean)
< 58	82	7(36.8 %)	75(53.6 %)	0.171
≥ 58	77	12(63.2 %)	65(46.4 %)
Histopathological gradea
Well	40	8(42.1 %)	32(22.9 %)	0.070
Moderate	98	8(42.1 %)	91(65.0 %)
Poor	20	3(15.8 %)	17(12.1 %)
Invasion depth
T1-T2	76	8(47.1 %)	68(51.1 %)	0.752
T3-T4	74	9(52.9 %)	65(48.9 %)
Lymphatic invasion
N0	68	6(33.3 %)	62(49.2 %)	0.207
N1-N3	76	12(66.7 %)	64(50.8 %)
TNM Staging
I/II	79	9(60.0 %)	70(64.2 %)	0.750
III/IV	45	6(40.0 %)	39(35.8 %)
HPV infection
Negative	67	4(28.6 %)	63(57.8 %)	0.039
Positive	56	10(71.4 %)	46(42.2 %)

P < 0.05 indicates a significant association among the variables

^a Well differentiation vs. moderate + poor differentiation