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. 2016 Apr 12;11:38. doi: 10.1186/s13023-016-0416-0

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© Marcé-Grau et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Brain MRI at age 18 days. Sagittal T1WI view showing thinning of the corpus callosum (arrow), with anterior predominance, and some degree of frontal lobe volume reduction (a). Axial T2WI view showing asymmetric enlargement of temporal subarachnoidal spaces (arrow) and mildly prominent sulci over the cerebral convexity, suggesting incipient atrophy. Myelination is delayed with minimal signals observed at the posterior limb of the internal capsule (arrowhead) and corpus callosum (b)