Figure 2. MPO activity is increased in lung tissue and airways after intratracheal LPS instillation in mouse model of lung injury/ARDS.
A, Schematic of mouse model of lung injury/ARDS. Balb/c mice are administered a 2 mg/kg dose of LPS by the intratracheal route. Neutrophilic inflammation and MMP activity were measured in the lung tissue and airways at 4, 12, 24, 48, and 72 hours after LPS treatment. B, Mouse lung MPO activity. C, Mouse BAL MPO activity. Data is expressed as mean ± SEM (n = 3–5).