Table 5.
Responses to TcpA of study participants by pregnancy status
| Infecting strain | Antibody (Study Days) | Pregnant (n=14) | Non-pregnant (n=130) | p-value | ||
|---|---|---|---|---|---|---|
| n | Median (IQR) | n | Median (IQR) | |||
| Overall | TcpA IgA | |||||
| Day 2 | 9 | 5 (2 – 5) | 79 | 6 (3 – 11) | 0.08 | |
| Day 7 | 9 | 13 (7 – 33) | 77 | 22 (7 – 46) | 0.91 | |
| Day 21 | 9 | 12 (9 – 37) | 76 | 11 (6 – 26) | 0.26 | |
| TcpA IgG | ||||||
| Day 2 | 7 | 30 (20 – 40) | 58 | 40 (24 – 65) | 0.21 | |
| Day 7 | 7 | 66 (65 – 142) | 56 | 64 (35 – 128) | 0.41 | |
| Day 21 | 7 | 90 (58 – 130) | 55 | 77 (44 – 120) | 0.47 | |
| V.cholerae O1 | TcpA IgA | |||||
| Day 2 | 7 | 3 (2 – 5) | 68 | 6 (3 – 11) | 0.07 | |
| Day 7 | 7 | 13 (6 – 23) | 66 | 23 (6 – 46) | 0.62 | |
| Day 21 | 7 | 12 (10 – 35) | 65 | 13 (6 – 27) | 0.44 | |
| TcpA IgG | ||||||
| Day 2 | 6 | 26 (20 – 35) | 57 | 42 (24 – 65) | 0.15 | |
| Day 7 | 6 | 66 (64 – 110) | 55 | 56 (35 – 123) | 0.65 | |
| Day 21 | 6 | 100 (51 – 131) | 54 | 76 (40 – 122) | 0.46 | |
| V. cholerae O139 | TcpA IgA | |||||
| Day 2 | 2 | 5 (4.6 – 4.9) | 11 | 5 (4 – 5) | 1.00 | |
| Day 7 | 2 | 104 (57 – 152) | 11 | 14 (7 – 36) | 0.43 | |
| Day 21 | 2 | 47 (28 – 66) | 11 | 10 (8 – 11) | 0.43 | |
| Tcp IgG | ||||||
| Day 2 | 1 | 43 (43 – 43) | 1 | 26 (26 – 26) | 0.32 | |
| Day 7 | 1 | 160 (160 – 160) | 1 | 127 (127 – 127) | 0.32 | |
| Day 21 | 1 | 90 (90 – 90) | 1 | 101 (101 – 101) | 0.32 | |
*
Patients presenting to the icddr,b Dhaka hospital with acute watery diarrhea (study day 1); Antibody titers, from patients at baseline on study day 2 and again at follow-up visits on study days 7 and 21.