Figure 1. Effector-mediated thermal inactivation of carnitine palmitoyltransferase II (considering only 1 binding site of the effector).

E represents the wild-type, E′ the variant S113L, N the native state, D the denatured state, K the equilibrium constant of the initial enzyme-effector binary complex, and k_in the microscopic first-order rate constant of the inactivation. The apostrophe indicates the parameters of the variant.