FIG. 2.

Activity of matrix metaloprotinase (A) (MMP)-9 and (B) MMP-2 in the cell free-BALF of BL/6 and C3H mice after 10, 16, and 22 weeks of of CS exposure. MMPs were assessed by zymography in the non-cellular supernatant fraction as described in Materials and Methods. Conditioned media from HT1080 cells was included on each zymogram, and the MMP signal from this samples were used to normalize all other signals. Data (n = 5–6 mice per group) were rank-transformed prior to ANOVA. Significant differences by pair-wise tests between groups (P < .05) are indicated by symbols above the bars as follows: *duration-, gender- and strain-matched differences from FA controls; ^#gender- and strain-matched differences from 10-week CS exposure; ^$duration- and gender-matched differences between CS-exposed C3H and BL/6 strains.