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. Author manuscript; available in PMC: 2016 Apr 13.
Published in final edited form as: Ann Neurol. 2014 Jul 29;76(3):379–392. doi: 10.1002/ana.24219

Fig 4. Linkage disequilibrium (LD, D') of top ranked SNPs.

Fig 4

LD was calculated in 1000 Genomes data from (A) Caucasians (CEU), (B) African Americans (AA), and (C) Asians (ASN). Top-ranked SNPs from PLXNA4 from each dataset are shown, namely rs277470, rs277472, and rs277484 in FHS; rs12539196 in NIA-LOAD, rs10273901 in ADGC Caucasians (ADGC-EA), rs75460865 in ADGC African Americans (ADGC-AA), and rs13232207 in ADGC Japanese (ADGC-JPN). The top SNP in the ADGC-AA dataset was monomorphic in both CEU and ASN populations. Five top-ranked SNPs (rs10273901, rs75460865, rs277470, rs277472, and rs277484) from the ADGC-EA and ADGC-AA samples were monomorphic in the ASN population. The top ranked SNPs are located in the SEMA domain, except rs10273901 and rs13232207 which are located in the cytoplasmic domain.