. Author manuscript; available in PMC: 2016 Apr 13.

Published in final edited form as: Ann Neurol. 2014 Jul 29;76(3):379–392. doi: 10.1002/ana.24219

Table 1.

Sample characteristics

Characteristics	Family Set		ADGC Set
Characteristics	FHS	NIA-LOAD	Caucasian	African American	Japanese
Total, N	2876	3828	18901	4896	1845
AD Cases, N	61	2530	9966	1459	951
Female %	54	63	58	70	64
Age at onset (AD cases), mean (SD)	82.8 (9.2)	73.3 (7.0)	76.4 (8.4)	79.4 (7.7)	73.0 (4.3)
Age at last exam (AD controls), mean (SD)	68.1 (10.6)	75.4 (11.6)	77.3 (7.7)	77.4 (8.2)	76.9 (6.0)
% of APOE ε4-carriers in cases	42.6	75.0	56.0	57.3	56.3
% APOE ε4-carriers in controls	21.6	36.6	21.5	34.7	15.9

FHS=Framingham Heart Study; NIA-LOAD=National Institute on Aging-Late Onset Alzheimer's Disease. ADGC replication set consisted of previously reported unrelated datasets from 14 Caucasian studies (excluding NIA-LOAD), 7 African American datasets (excluding NIA-LOAD), and one Japanese dataset.