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. Author manuscript; available in PMC: 2016 Apr 13.
Published in final edited form as: ACS Chem Neurosci. 2015 May 1;6(8):1411–1419. doi: 10.1021/acschemneuro.5b00092

Figure 4.

Figure 4

Bias factors (ΔΔLogR values) and relative activity ratios represented. (A) Relative activity of each test agonist (Emax/EC50) is presented relative to the reference agonist U69,593. (B) Bias factors were calculated using the operational model and are presented as the degree of bias toward G protein coupling and away from βarr2 recruitment and toward G protein coupling and away from ERK 1/2 phosphorylation relative to U69,593. The center of each figure presents a value equal to one (as defined by the reference agonist). The bias factor of the reference agonist is equal to one and the values greater than one indicate bias toward G protein coupling compared to βarr2 recruitment or ERK phosphorylation. Values can be found summarized in Table 2.