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. Author manuscript; available in PMC: 2016 Apr 13.
Published in final edited form as: ACS Chem Neurosci. 2015 May 1;6(8):1411–1419. doi: 10.1021/acschemneuro.5b00092

Figure 5.

Figure 5

Schematic summarizing the SAR trends revealed when comparing the ratio of Bias Factors for each assay. Ratios were generated by dividing the bias factors for G protein vs βarr2 by the bias factors for G vs ERK1/2 activation from Table 2. A trend can be seen wherein the thiophenyl substitution increases the bias between G protein and ERK activation (denominator) resulting in a decrease in the ratio. The pyridyl substitution decreases the bias for G protein vs ERK activation (denominator) producing an increase in the ratio.