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. Author manuscript; available in PMC: 2016 Apr 13.
Published in final edited form as: ACS Chem Neurosci. 2015 May 1;6(8):1411–1419. doi: 10.1021/acschemneuro.5b00092

Table 2.

Parameter Estimates and Bias Factors Produced by Fitting to the Operational Modela

entry ΔLogR
ΔΔLogR(assay1−assay2)
bias factor (10ΔΔLogR)
G protein assay βarrestin2 assay ERK 1/2 ΔΔLogR(G−βarr2) 95% CI ΔΔLogR(G−ERK) 95% CI G/βarr2 G/ERK
U69,593        0        0        0    0    0     1     1
1.1   0.28 ± 0.16 −1.39 ± 0.11 −1.69 ± 0.26 1.7 ± 0.19 1.2–2.1 2.0 ± 0.19 1.5–2.4   47   93
1.2   0.59 ± 0.12 −1.50 ± 0.21 −1.93 ± 0.18 1.9 ± 0.21 1.6–2.5 2.6 ± 0.19 2.2–3.1 122 419
1.3 −0.34 ± 0.09 −1.50 ± 0.15 −1.29 ± 0.06 1.2 ± 0.20 0.7–1.6 1.0 ± 0.19 0.5–1.4   15     9
2.1   0.30 ± 0.13 −1.39 ± 0.13 −1.64 ± 0.10 1.7 ± 0.19 1.3–2.1 1.9 ± 0.19 1.5–2.4   49   88
2.2   0.33 ± 0.19 −1.19 ± 0.10 −1.97 ± 0.20 1.5 ± 0.19 1.1–2.0 2.5 ± 0.19 1.9–3.0   33 304
2.3   0.01 ± 0.12 −1.40 ± 0.20 −1.21 ± 0.01 1.4 ± 0.22 0.9–1.9 1.2 ± 0.22 0.7–1.7   25   16
3.1 −0.34 ± 0.16 −1.58 ± 0.11 −1.93 ± 0.09 1.2 ± 0.20 0.8–1.7 1.7 ± 0.20 1.2–2.1   17   47
3.2 −0.24 ± 0.17 −1.09 ± 0.09 −1.82 ± 0.10 0.9 ± 0.22 0.4–1.3 1.7 ± 0.22 1.2–2.2     7   46
3.3 −0.55 ± 0.14 −2.12 ± 0.16 −1.63 ± 0.06 1.6 ± 0.22 1.1–2.1 1.1 ± 0.19 0.7–1.6   37   14
a

The parameter estimates are presented as mean ± SEM (n ≥ 3). The ΔΔLogR for each bias calculation is presented ± SEM (n ≥ 3) along with 95% confidence interval (95% CI). Bias factor is calculated as the antilog of the ΔΔLogR for each response pair.