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. 2016 Apr 13;3:16017. doi: 10.1038/mtm.2016.17

Table 4. Results of large-scale downstream processing of VSV-g-pseudotyped LV vectors.

Company/institution Concentration factor (x) Overall yield (%) Final titer
Beckman Research Institute61 150–200 (use of ultracentrifugation) 40 2.6–3.8 × 108 TU/ml
Virxsys52 20 30 2.17 × 108 TU/ml
Généthon42/MolMed105 50/100 20 1–2 × 109 IG/ml
Oxford Biomedica/Henogen (Mitrophanous, personal communication) 2,000 (use of two succeeding TFF steps) 30–40 0.1–2 × 109 TU/ml
St. Jude Children’s Hospital56 65–80 29–33 4.5–7.2 × 108 TU/ml

LV, lentiviral vectors; VSV-g, glycoprotein of the vesicular stomatitis virus.