. Author manuscript; available in PMC: 2017 Feb 20.

Published in final edited form as: J Drug Alcohol Res. 2016 Feb 20;5:235970. doi: 10.4303/jdar/235970

Table 1.

Affinity of cocaine and methamphetamine (METH) at sigma-1 receptor (Sig-1R) and sigma-2 receptor (Sig-2R)

	Sample/Reference	Affinity for Sig-1R	Affinity for Sig-2R
Cocaine	Rat cerebellum, [59]	6.7 ± 0.3 μM^*1
	Mouse brain, [56]	2 ± 0.2 μM^*2	31 ± 4 μM^*3
	Guinea pig brain minus cerebellum, [57]	5190 (3800–7060) nM^*2	19,300 (16,000–23,300) nM^*3
METH	Rat brain, [55]	2.16 ± 0.25 μM^*2	46.67 ± 10.34 μM^*3
METH	Guinea pig brain minus cerebellum, [58]	4390 (3740–5160) nM^*2	15,900 (11,700–21,500) nM^*3

^*1

in competition with Haloperidol

^*2

in competition with (+)-Pentazocine

^*3

in competition with DTG in the presence of (+)-Pentazocine