Table 2.

Peak concentrations of cocaine and methamphetamine (METH) in the blood, plasma, or brain

	Drug administrating condition/Reference	Blood or Plasma	Brain
Acute cocaine	Mouse, 10 mg/kg, ip, [46]	0.75 μg/ml	2.6 μg/g
	Mouse, 25 mg/kg, ip, [46]	1.5 μg/ml	6.7 μg/g
	Rat, 8 mg/kg, iv, [44,45]	0.61 ± 0.06 μg/ml	7.27 ± 0.18 μg/g
	Rat, 20 mg/kg, sc, [44,45]	0.49 ± 0.06 μg/ml	3.44 ± 0.36 μg/g
	Rat, 30 mg/kg, ip, [43]	2.7 μM	1.41 ± 0.09 μM*
Chronic cocaine	Rat, 20 mg/kg, sc for 3 weeks, twice a day, [44]	0.50 ± 0.10 μg/ml	3.05 ± 0.14 μg/g
	Rat, 10–20 mg/kg, sc for 10 or 30 days, once a day,	10 days, 4.1 μM	10 days, 2.62 μM*
	30 mg/kg, ip on the test day, [43]	30 days, 5.5 μM	30 days, 1.8 μM*
	Human, 20.5 mg, iv, [48]	180 ± 56 ng/ml
	Human, 94.6 mg, ni, [48]	220 ± 50 ng/ml
	Human, 50 mg, si, [48]	203 ± 88 ng/ml
Acute METH	Mouse, 2.5 mg/kg, ip, [47]		2.63 ± 0.27 μg/g
	Mouse, 5.0 mg/kg, ip, [47]		4.96 ± 0.35 μg/g
	Mouse, 10 mg/kg, ip, [47]		8.90 ± 0.40 μg/g
	Rat, 1 mg/kg, sc, [51]	7.5 ng/ml	70 ng/g
	Rat, 5 mg/kg, sc, [51]	40 ng/ml	300 ng/g
	Rat, 0.5 mg/kg, iv, [52]	0.54 ± 0.07 μM
	Rat, 2.5 mg/kg, iv, [54]	1.0 ± 0.1 μg/ml
Chronic METH	Rhesus monkey, 0.32 mg/kg, im, [53]	51.0 ± 8.5 ng/ml
	Human, 30 mg, iv, [50]	175 ng/ml
	Human, 15.5 mg, iv, [49]	100 ng/ml

^*Extracellular concentrations in the nucleus accumbens