Fig. 7.

[Ca^2 +]_o-induced IKCa currents in freshly isolated ECs. (A) Representative trace and (B) the mean I/V relationships of perforated-patch recordings showing that increasing [Ca^2 +]_o from 1 mM to 6 mM evoked currents which were inhibited by Calhex-231 (3 µM) but were unaffected by L-NAME (300 µM). (C) and (D) show that [Ca^2 +]_o-induced currents were also inhibited by the addition of CbTX (100 nM) but were unaffected by apamin (300 nM). All points are from n = 6 patches from at least n = 3 animals.