Table.
Clinical Characteristics and Japanese Ministry of Health and Welfare Criteria in Patients with Biopsy Specimen– Proven Cardiac Sarcoidosis and Cardiomyopathy
| Variable | Mean ± SD or No. (%) |
|---|---|
| (N = 27) | |
| Age, y | 53.8 ± 9.5 |
| Male | 16 (59) |
| Caucasian | 21 (78) |
| NYHA Functional Classification III–IV | 18 (67) |
| Hypertension | 15 (56) |
| Hyperlipidemia | 12 (44) |
| Smoking | 5 (19) |
| Obese | 5 (19) |
| Diabetes | 6 (22) |
| Coronary artery disease (CABG or PCI) | 5 (19) |
| Atrial fibrillation | 10 (37) |
| Anemia | 8 (30) |
| Implantable cardioverter defibrillator | 23 (85) |
| Ventricular tachycardia | 16 (59) |
| Heart transplantation | 19 (70) |
| Left ventricular assist device | 5 (9) |
| eGFR, ml/min/1.73 m2 | 75 ± 22 |
| Ejection fraction, % | 27 ± 11 |
| Electrocardiogram findings | |
| QRS duration, msec | 135 ± 30 |
| Left bundle branch block or IVCD | 3 (11) |
| Right bundle branch block | 7 (26) |
| JMHW major criteria | |
| Extracardiac involvement | 13 (48) |
| Advanced atrioventricular block | 15 (56) |
| Depressed left ventricular ejection fraction | 27 (100) |
| Basal septal thinning | 4 (15) |
| JMHW minor criteria | |
| Abnormal electrocardiogram findings | 27 (100) |
| Nuclear imaging perfusion defect (n = 16) | 16 (100) |
| Gadolinium-enhanced CMR (n = 12) | 12 (100) |
CABG, coronary artery bypass graft; CMR, cardiac magnetic resonance imaging; eGFR, estimated glomerular filtration rate by the Chronic Kidney Disease Epidemiology Collaboration formula; IVCD, intraventricular conduction defects; JMHW, Japanese Ministry of Health and Welfare; NYHA, New York Heart Association; PCI, percutaneous coronary intervention.