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. Author manuscript; available in PMC: 2016 Apr 13.
Published in final edited form as: Nature. 2015 Aug 5;524(7564):247–251. doi: 10.1038/nature14884

Figure 4. Model of individual versus complexed class A and class B J-protein function in protein disaggregation.

Figure 4

Size-specific aggregate targeting: large aggregates are targeted by J-proteinclass B–HSP70–HSP110 (blue); small aggregates are targeted by J-proteinclass A–HSP70–HSP110 (green); all aggregates sizes are targeted by J-protein-mixed-class-complex–HSP70–HSP110 (magenta).HSP70 molecules are in grey. Sequential reaction steps (encircled numbers): 1, J-protein targets aggregate; 2, J-protein recruits HSP70; 3, surface-bound chaperones generate pulling forces (dashed red arrows); and 4, polypeptide extraction leading to protein disaggregation. Chaperone recruitment denoted by dashed black arrows.