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. Author manuscript; available in PMC: 2016 Oct 21.
Published in final edited form as: ACS Chem Neurosci. 2015 Aug 5;6(10):1683–1695. doi: 10.1021/acschemneuro.5b00123

Figure 1.

Figure 1

Impaired acquisition of a visual pairwise discrimination task involving top-down processing in M1 KO mice. (A) Stimuli chosen for pairwise discrimination: stimulus 1, “lasers”, and stimulus 2, “4 circles”. (B) Wild-type (WT) and M1 KO mice demonstrate an inherent preference for stimulus 2 when responding on either stimulus was reinforced. (C) M1 KO mice required a greater number of days to acquire the discrimination when discriminating the less salient stimulus (stimulus 1, S+) from the more salient stimulus (stimulus 2, S−). *, p < 0.05; ***, p < 0.001.