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. Author manuscript; available in PMC: 2016 Apr 13.
Published in final edited form as: Clin Exp Metastasis. 2010 Mar 12;27(4):217–231. doi: 10.1007/s10585-010-9320-5

Figure 3. Examples of extrapulmonary lesion regression under treatment with scFv 1.

Figure 3

(A) F-luc tagged, in vivo selected and highly metastatic MDA-MB-435-met cells were injected i.v. to induce multiorgan metastasis. Metastatic progression was monitored by non-invasive bioluminescence imaging (photons/second/cm2) over time. In these examples, the location of renal lesions is circled and shown 3 days before treatment, at the beginning of treatment, and after 3 daily doses of scFv1 phage. (B) Fold-change in renal lesion growth, calculated based on signal change during 3 days before and 3 days under treatment.