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Antibody-dependent cytotoxicity of NK cells toward PC-3, NB1691 or M21 cells. A) Schematic illustration of HGNPs stimulating the attacks on GD2 positive cells by NK cells and inducing immune-mediated cancer cell killing through ADCC. B, C). Cytotoxicity of HGNPs in present of NK cells. Cells were incubated with NK cells with hu14.18K322A or HGNPs at equivalent hu14.18K322A concentration of 3.3 nM for 4 hr. The ratio of NK cells to PC-3, NB1691 or M21 cells was 1:1 in B) and 5:1 in C).
