| Title |
Missense alterations of BRCA1 gene detected in diverse cancer patients. |
| Introduction/Background |
BRCA1 gene mutations may also be related with other types of cancers such as prostate cancer and colorectal cancer. |
| Methods/Aims |
We used PCR-NIRCA and PCR-SSCP methods for screening the BRCA1 mutation hot regions, exons 2, 5, 11, 16 and 20. |
| Results |
We have identified a rare sequence variant, A3537G (Ser 1140Gly) in a B cell lymphoma patient and two polymorphisms, A1186G (Gln356Arg) in a brain cancer patient and A3667G (Lys1183Arg) in a germline tumor patient. |
| Conclusion |
In conclusion, 3 missense alterations of BRCA1 gene have been identified in cancers other than breast cancer. |
