Fig 1. Comparison of clinical outcomes in ibuprofen and placebo groups.

Sixteen calves were experimentally infected with bovine respiratory syncytial virus by nebulizer on Day 0. Eight received ibuprofen and received eight placebo. (A) Shows the mean clinical score by treatment group for each day. The groups were statistically significantly different by Day 5 using a mixed effects model. (B) Shows the time taken to enter the most severe decile of illness as measured by the clinical score. Statistical significance was calculated using the log rank test. (C) Shows the percentage weight gain for each individual calf. Calves randomized to ibuprofen are in red; placebo is in blue. Statistical significance was calculated using ordinary least squares regression. (D) Shows the mean temperature by treatment group. Temperature was measured every eight hours. (E) Shows the mean respiratory rate per group. Respiratory rate was measured every eight hours. Statistical significance was calculated for both temperature and respiratory rate using a mixed effect model. (F) Shows the time taken to enter the most severe decile of tachypnea. Statistical significance for (F) was calculated using the log rank test.