Fig 2. Disruptive mutations in bird MOXD2.

ORF-disrupting mutations in exon 1 (A) and exon 4 (B) of representative birds are presented. Deleterious mutations, including nonsense codons, insertions, deletions, and splice-site mutations, are highlighted using a red background. Start codons and splice donor and acceptor sequences are highlighted using a yellow background. Amino acid sequences of the rifleman are shown above the DNA sequence alignments. Exonic and intronic sequences are in uppercase and lowercase letters, respectively. See S3 Fig for more disruptive mutations in other exons.