FIGURE 3.
(A) Pre-Op and Post-Op (6 months) quality of life assessment of patients undergoing functional endoscopic sinus surgery as a function of polyp status and PTC taste sensitivity. Patients were classified based on the presence or absence of nasal polyps and were asked to rate the bitterness of the PTC with a taste test on a scale of 0 to 12. Patients were characterized as sensitive to PTC (≥5) or insensitive (<5). (B) Pre-Op and Post-Op (6 months) quality of life assessment of patients undergoing functional endoscopic sinus surgery as a function of polyp status and PTC taste sensitivity. Surgical outcomes as measured by the change in quality of life assessment (SNOT-22: pre-post) based on PTC sensitivity and polyp status. In nonpolypoid patients TAS2R38 taste sensitivity to PTC significantly correlates with favorable vs suboptimal outcomes (*p < 0.05). ns = not significant; PAV = functional receptor haplotype containing proline, alanine, and valine; Post-Op = postoperative; Pre-Op = preoperative; PTC = phenylthiocarbamide; SNOT-22 = 22-item Sino-Nasal Outcome Test.