. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: Int Forum Allergy Rhinol. 2015 Nov 12;6(1):25–33. doi: 10.1002/alr.21666

TABLE 3.

Multivariate mixed model regression of factors associated with increased SNOT improvement in all patients undergoing sinus surgery for CRS^*

Analysis by genotype (n = 207)	SNOT improvement^a	95% CI	P
PAV genotype	20	8 to 32	0.001
Polyps	14	8 to 20	<0.001
Interaction: genotype/polyps			0.007
Male gender	1	−4 to 7	0.65
White	−4	−12 to 5	0.36
Age ≥50 years	−3	−8 to 2	0.23

Results were likewise significant for the 123 initial patients in the study (p < 0.001 For a difference based on PAV genotype, polyps, and the interaction term). Bole values of p are significant.

Mixed-effects, generalized-least-squares multivariate regression model for change between preoperative SNOT-22 score and postoperative scores at 1, 3, and 6 months. Genotype, age, gender, race/ethnicity, and any significant variables (p < 0.05) on analysis of outcomes were incorporated, as well as an interaction term between genotype and polyp status.

CI = confidence interval; CRS = chronic rhinosinusitis; PAV = functional receptor naplotype containing proline, alanine, and valine; SNOT-22 = 22-item Sino-Nasal Outcome Test.